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Norihiro Kokudo Selected Research

huachansu

1/2017Combination of Cinobufacini and Doxorubicin Increases Apoptosis of Hepatocellular Carcinoma Cells through the Fas- and Mitochondria-Mediated Pathways.
2/2012Induction of apoptosis by cinobufacini preparation through mitochondria- and Fas-mediated caspase-dependent pathways in human hepatocellular carcinoma cells.
3/2011Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor.
12/2010Chinese herbal medicines as adjuvant treatment during chemo- or radio-therapy for cancer.
7/2010Apoptosis-inducing activity of compounds screened and characterized from cinobufacini by bioassay-guided isolation.
4/2010Cinobufacini, an aqueous extract from Bufo bufo gargarizans Cantor, induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells.
1/2010Anti-hepatitis B virus activities of cinobufacini and its active components bufalin and cinobufagin in HepG2.2.15 cells.

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Norihiro Kokudo Research Topics

Disease

153Neoplasms (Cancer)
08/2022 - 05/2003
134Hepatocellular Carcinoma (Hepatoma)
04/2022 - 05/2003
70Neoplasm Metastasis (Metastasis)
06/2022 - 05/2003
19Fibrosis (Cirrhosis)
11/2020 - 11/2003
18Hepatitis C
11/2017 - 01/2004
17Infections
08/2021 - 11/2003
16Colorectal Neoplasms (Colorectal Cancer)
02/2020 - 01/2006
15Liver Neoplasms (Liver Cancer)
10/2021 - 05/2003
12Hemorrhage
04/2022 - 09/2003
12Cholangiocarcinoma
08/2021 - 04/2007
12End Stage Liver Disease
08/2019 - 10/2005
12Liver Cirrhosis (Hepatic Cirrhosis)
11/2017 - 11/2002
11Stomach Neoplasms (Stomach Cancer)
02/2022 - 05/2003
11Pancreatic Neoplasms (Pancreatic Cancer)
01/2019 - 12/2009
11Hepatitis B
11/2017 - 11/2003
10Liver Failure
04/2021 - 01/2004
10Liver Diseases (Liver Disease)
03/2016 - 09/2006
9Adenocarcinoma
08/2022 - 01/2006
9Lymphatic Metastasis
12/2021 - 01/2005
8Hepatitis
01/2016 - 05/2003
8Carcinoma (Carcinomatosis)
06/2015 - 05/2005
7Thrombosis (Thrombus)
04/2022 - 01/2005
6Sclerosing Cholangitis
01/2021 - 09/2008
6Portal Hypertension
11/2019 - 06/2008
6Ascites
08/2019 - 01/2009
6Body Weight (Weight, Body)
05/2019 - 02/2011
6Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
01/2018 - 07/2005
5Necrosis
04/2022 - 01/2012
5Neuroendocrine Tumors (Neuroendocrine Tumor)
01/2022 - 03/2015
5Pancreatic Fistula (Pancreatic Fistulas)
11/2017 - 07/2008
4Pathologic Constriction (Stenosis)
01/2022 - 05/2005
4Peritonitis
01/2019 - 10/2015
4Hypertension (High Blood Pressure)
01/2019 - 06/2014
4Biliary Atresia
04/2018 - 01/2007
4Coinfection
11/2017 - 02/2011
4Inflammation (Inflammations)
01/2017 - 10/2008
4Acute Liver Failure (Fulminant Hepatic Failure)
01/2016 - 10/2008
3Acute Kidney Injury (Acute Renal Failure)
12/2021 - 10/2005
3Wounds and Injuries (Trauma)
09/2019 - 01/2012

Drug/Important Bio-Agent (IBA)

27Indocyanine Green (Cardio-Green)FDA LinkGeneric
10/2022 - 02/2009
15acarboxyprothrombin (PIVKA)IBA
04/2014 - 05/2003
14Tumor Biomarkers (Tumor Markers)IBA
10/2019 - 05/2003
11MucinsIBA
01/2021 - 01/2006
11Proteins (Proteins, Gene)FDA Link
01/2018 - 05/2003
10Messenger RNA (mRNA)IBA
01/2020 - 02/2009
10Biological ProductsIBA
11/2017 - 10/2006
9alpha-Fetoproteins (alpha-Fetoprotein)IBA
01/2020 - 10/2009
9Biomarkers (Surrogate Marker)IBA
01/2018 - 11/2008
8BilirubinIBA
04/2020 - 11/2003
8AlbuminsIBA
08/2019 - 08/2009
8InterferonsIBA
10/2017 - 12/2005
8Hepatitis B Surface Antigens (HBsAg)FDA Link
03/2016 - 11/2003
8Prothrombin (Factor II)IBA
10/2015 - 12/2008
7Ribavirin (Virazole)FDA LinkGeneric
08/2017 - 12/2005
7huachansuIBA
01/2017 - 01/2010
6Antiviral Agents (Antivirals)IBA
04/2021 - 01/2010
6Sorafenib (BAY 43-9006)FDA Link
01/2020 - 09/2010
6AntigensIBA
05/2016 - 12/2009
5UracilIBA
10/2021 - 10/2006
5TegafurIBA
10/2021 - 10/2006
5DNA (Deoxyribonucleic Acid)IBA
08/2021 - 07/2006
5EnzymesIBA
01/2020 - 01/2010
5Pharmaceutical PreparationsIBA
12/2016 - 01/2005
4Oxaliplatin (Eloxatin)FDA LinkGeneric
02/2021 - 10/2010
4GemcitabineFDA Link
01/2019 - 06/2010
4GadoliniumIBA
02/2018 - 11/2009
4AntibodiesIBA
01/2018 - 03/2013
4asunaprevirIBA
11/2017 - 01/2015
4daclatasvirIBA
11/2017 - 01/2015
4Indicators and Reagents (Reagents)IBA
10/2017 - 01/2006
4Immunoglobulins (Immunoglobulin)IBA
03/2016 - 11/2003
4Alanine Transaminase (SGPT)IBA
06/2015 - 08/2009
4N-Acetylneuraminic Acid (Sialic Acid)IBA
04/2015 - 01/2007
4CarbohydratesIBA
04/2015 - 08/2008
4beta CateninIBA
01/2015 - 11/2008
4CateninsIBA
08/2014 - 02/2011
4minaprine (Cantor)IBA
02/2014 - 04/2010
3Cetuximab (Erbitux)FDA Link
06/2022 - 07/2014
3Bevacizumab (Avastin)FDA Link
01/2022 - 10/2015
3Leucovorin (Folinic Acid)FDA Link
10/2021 - 02/2014

Therapy/Procedure

103Liver Transplantation
08/2021 - 11/2003
84Hepatectomy
08/2022 - 05/2003
49Therapeutics
04/2022 - 12/2004
28Drug Therapy (Chemotherapy)
06/2022 - 11/2008
19Pancreaticoduodenectomy
08/2022 - 05/2005
13Transplantation
01/2021 - 01/2004
10Radiofrequency Ablation
04/2022 - 08/2010
8Adjuvant Chemotherapy
04/2022 - 04/2007
8Operative Surgical Procedures
01/2021 - 09/2004
6Esophagectomy
03/2022 - 02/2006
6Contraindications
11/2019 - 06/2008
6Chinese Traditional Medicine (Traditional Chinese Medicine)
01/2017 - 04/2010
6Blood Transfusion (Blood Transfusions)
11/2015 - 04/2007
5Neoadjuvant Therapy
03/2022 - 10/2006
5Gastrectomy
01/2016 - 05/2003
4Colectomy
10/2020 - 10/2008
4Renal Dialysis (Hemodialysis)
01/2019 - 10/2005
3Lymph Node Excision (Lymph Node Dissection)
08/2022 - 04/2009
3Segmental Mastectomy (Lumpectomy)
06/2020 - 02/2013
3Metastasectomy
01/2020 - 09/2012